PROGESTERONE PROMETRIUM UTROGESTAN 100 MG 30 CAPS

INDICATIONS: UTROGESTAN is indicated as replacement therapy or peri menopause has also been used in the premenstrual syndrome, dysfunctional uterine bleeding, in high sterility and luteal insufficiency, benign breast disease and threatened abortion. Pharmacokinetics: Approximately 60% of an oral dose is absorbed UTROGESTAN intestine. Subsequently liver these substances are partially metabolized. Peak plasma levels are achieved after one to four hours. There are interindividual differences, but these differences appear to be minor. Please consult your physician before taking any medication. The bioavailability (defined as the area under the curve) is linear and is dose related. The major metabolites in plasma are the biologically active 20 a-dihydroxyprogesterone and inactive where pregnanediol predominates. Most of progesterone and its metabolites, which have reached the systemic circulation, they are excreted by the kidneys, mainly as metabolites glucuroneos pregnanediol and pregnenolone.